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Alzheimer’s and Parkinson’s are diseases of the brain in which gradual degeneration of neurons leads to loss of speech, memory, and thinking. Existing remedies are aimed only at suppressing symptoms, but cannot stop the process of neurodegeneration itself. Now Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer’s, Parkinson’s, and other severe brain pathologies. New molecules of pyrrolyl- and indolylazine classes activate intracellular mechanisms to combat one of the main causes of “aged” brain diseases—an excess of so-called amyloid structures that accumulate in the human brain with age. Experts from various institutes including Ural Federal University took part in the study, published in the European Journal of Medicinal Chemistry. “Our compounds activate the synthesis of specific heat shock proteins and cause their accumulation in the cell,” said research co-author, professor of the Department of Organic and Biomolecular Chemistry at UrFU Irina Utepova. Important advantages of compounds from the series of pyrrolyl- and indolylazine classes are a profitable synthesis technology and low toxicity.

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