Georgia Lab Experiments Shows CBD Reduces Plaque And Improves Cognition in Early Onset Alzheimer’s

DM

A two-week course of high doses of CBD helped restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer’s disease, and improved cognition in an experimental model of early onset familial Alzheimer’s—a form of Alzheimer’s that doctors know for certain is linked to genes—investigators report. The proteins TREM2 and IL-33 are important to the ability of the brain’s immune cells to literally consume dead cells and other debris like the beta-amyloid plaque that piles up in patients’ brains—and levels of both are decreased in Alzheimer’s. The researchers report for the first time that CBD normalizes levels and function, improving cognition by more than seven-fold as it reduces levels of the immune protein IL-6 in mice, which is associated with the high inflammation levels found in Alzheimer’s, says Dr. Babak Baban, immunologist and associate dean for research in the Dental College of Georgia and the study’s corresponding author. He joined colleagues at the Medical College of Georgia, writing in the Journal of Alzheimer’s Disease.

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